KPV 5mg Tripeptide Research Peptide

For Research Purposes Only. Not approved for human consumption.

KPV Tripeptide Research Peptide 5mg

KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte stimulating hormone (alpha-MSH) that retains its potent anti-inflammatory properties. KPV binds melanocortin receptors (MC1R, MC3R) and inhibits NF-kB nuclear translocation — a central inflammatory signaling pathway. Its small size (3 amino acids) allows cellular penetration that larger peptides cannot achieve, making it particularly effective in gastrointestinal and skin inflammation research models.

Research Applications

• Intestinal inflammation and IBD research models
• NF-kB pathway inhibition studies
• Skin inflammatory condition research
• Cellular penetration and delivery studies
• Anti-inflammatory mechanism investigations

Quality Specifications

• Purity: ≥98% (HPLC verified)
• Compound: KPV
• Molecular Weight: 340.4 Da
• Form: Lyophilized powder
• Storage: -20°C, protect from light
• COA: Batch-specific, ISO-accredited laboratory

Frequently Asked Questions

Q: How does KPV exert anti-inflammatory effects?
A: KPV binds melanocortin receptors MC1R and MC3R and inhibits NF-kB nuclear translocation — preventing transcription of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6.

Q: Why is KPV particularly effective in gut research?
A: Its small tripeptide structure allows intestinal cellular penetration that larger peptides cannot achieve. Research has shown direct effects on intestinal epithelial cells and colonocytes.

Q: How does KPV relate to alpha-MSH?
A: KPV represents the C-terminal tripeptide (positions 11-13) of alpha-MSH. Research suggests this region is primarily responsible for alpha-MSH’s anti-inflammatory activity.

Related Research: GHK-Cu + KPV Blend

For laboratory research use only. Not for human consumption. Not evaluated by the FDA.